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T7700 |
Lersivirine
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Lersivirine(UK 453061),UK-453061 |
HIV Protease
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Reverse Transcriptase
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Lersivirine (UK-453061)(UK 453061) is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) under development for HIV infection therapy. |
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T15409 |
GNF179
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Parasite
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GNF179 is an optimized 8,8-dimethyl IP analog. It exhibited the potency(4.8 nM against the multidrug resistant strain W2) in vitro metabolic stability and in vivo oral bioavailability. |
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T11888 |
LtaS-IN-1
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Others
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Antibacterial
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T11445 |
GNF179 (Metabolite)
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GNF179 Metabolite |
Others
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GNF179 Metabolite, the derivative of GNF179—an optimized 8,8-dimethyl IP analog—demonstrates significant potency (4.8 nM against the multidrug-resistant W2 strain) alongside in vitro metabolic stability and in vivo oral ... |
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T80395 |
Abaecin
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Abaecin, an antibacterial peptide, exhibits selective efficacy against an Apidaecin-resistant strain of Xanthomonas [1]. |
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T72717 |
Anti-IAV agent 1
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Anti-IAV Agent 1-1a is an orally administered compound effective against the Influenza A virus (IAV), demonstrating inhibitory concentration 50 (IC50) values of 0.03 μM and 0.06 μM for the H1N1 strain and the Oseltamivir... |
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T62600 |
RYL-552S
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RYL-552S is a drug-resistant strain of Plasmodium falciparum that effectively kills the asexual blood stage of the parasite in vitro. |
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T63865 |
Antimycobacterial agent-3
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Antimycobacterial agent-3 is an antimycobacterial agent with low cytotoxicity. antimycobacterial agent-3 is effective against sensitive MTB strain H37Rv and resistant clinical isolates (MIC < 0.029-0.110 μ M). |
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T35485 |
6-Prenylindole
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6-Prenylindole is a bacterial metabolite that has been found in Streptomyces and has antifungal and antimalarial properties.1 It is active against A. brassicicola strain TP-F0423 and F. oxysporum f. sp. tulipae TU-4-2 (1... |
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T60302 |
4,4'-Dicyanostilbene
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4,4'-Dicyanostilbene (compound 43) demonstrates potent antimalarial activity against the Dd2 strain, exhibiting an EC50 value of 27 nM, and exhibits in vivo efficacy against methicillin-resistant Staphylococcus aureus (M... |
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T79379 |
Antitubercular agent-39
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Antitubercular agent-39 (Compound P1) is a potent agent effective against both drug-resistant strains and drug-susceptible clinical isolates of tuberculosis, exhibiting inhibition of the Mtb strain H37Rv with a minimum i... |
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T79440 |
DprE1-IN-5
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DprE1-IN-5 (Compound 10), a potent DprE1 inhibitor, exhibits anti-TB activity with an MIC of 4 μM against the Mtb H37Rv strain and demonstrates antimycobacterial efficacy against drug-resistant strains. Additionally, it ... |
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T79441 |
DprE1-IN-6
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DprE1-IN-6 (Compound 56) is a DprE1 inhibitor with demonstrated anti-TB activity, exhibiting a minimum inhibitory concentration (MIC) of 1 μM against the Mtb H37Rv strain, along with efficacy against drug-resistant mycob... |
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T79281 |
Antimycobacterial agent-6
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Antimycobacterial agent-6 (compound 25) effectively inhibits Mycobacterium tuberculosis, including wild-type and fluoroquinolone-resistant strains, by targeting the Mtb DprE1-C387S mutant. It displays minimal inhibitory ... |
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T36183 |
Neospiramycin I
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Neospiramycin I is a macrolide antibiotic and derivative of spiramycin I.1It is active against the macrolide-sensitive KB210, but not the macrolide-resistant KB224, strain ofS. aureus(MICs = 3.12 and >100 μg/ml, respecti... |
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T79442 |
DprE1-IN-7
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DprE1-IN-7 (Compound 64) is a DprE1 inhibitor with potent anti-tuberculosis (TB) activity, demonstrating a minimum inhibitory concentration (MIC) of 1 μM against the Mtb H37Rv strain. It exhibits antimycobacterial effect... |
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T80279 |
Urumin
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Influenza Virus
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Urumin, a compound with antiviral properties, inhibits human influenza A virus growth, particularly the PR8 strain, with an inhibitory concentration (IC 50) of 3.8 μM. It acts by targeting the conserved stalk of H1 hemag... |
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T79632 |
Antileishmanial agent-21
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Parasite
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Antileishmanial agent-21 (compound 4e) functions as an inhibitor of Leishmania pteridine reductase 1 (Lm-PTR1), employing an anti-folate mechanism. Its antileishmanial effects can be negated by folic acid and leucovorin.... |
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T78925 |
HIV-1 inhibitor-58
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HIV-1 Inhibitor-58 (Compound 10c) is a non-nucleoside reverse transcriptase inhibitor with broad-spectrum antiviral properties, effective against both wild-type strain IIIB and NNRTI-resistant strains like K103N and E138... |
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T83899 |
N-didesmethyl Loperamide
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R 21345 |
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N-didesmethyl Loperamide, an active metabolite of the peripheral μ1-opioid receptor agonist loperamide, impedes electrically induced contractions in isolated guinea pig myenteric plexus (IC50 = 370 nM) and enhances the s... |
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T35902 |
Milbemycin A4 oxime
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Milbemycin A4 oxime is a derivative of milbemycin A4 and a component of milbemycin oxime , compounds that both have insecticidal and nematocidal activity. Milbemycin A4 oxime (0.05 mg/kg) reduces the number of microfilar... |
